Synaptic vesicle priming

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle priming pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PREP, PNPLA4, and KNL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle priming activity versus PREP in KIDNEY (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PREP →	+0.609	+0.308	.007	.007	3	4
SKIN	PNPLA4 →	+1.124	+0.180	.006	.008	3	4
KIDNEY	KNL1 →	+1.595	+0.382	.003	.005	3	4
BLOOD_Myeloma	MAP3K21 →	-2.047	-0.334	.001	.006	3	4
BLOOD_Myeloma	DGKA →	-3.574	-0.287	.006	.008	3	4
LIVER	RHCE →	+0.282	+0.232	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016082 vs PREP — KIDNEY

Explore this scatter interactively →