Synaptic vesicle docking

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle docking pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K9, CXCR4, and MIR4799, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle docking activity versus MAP3K9 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP3K9 →	+1.062	+0.867	<.001	<.001	3	4
GBM	CXCR4 →	-0.787	-0.733	.001	<.001	3	4
GBM	MIR4799 →	-0.837	-0.699	.001	<.001	3	4
OV	AKR7A3 →	+0.622	+0.747	.001	<.001	2	4
OV	EBF4 →	+0.780	+0.595	.004	<.001	3	3
LSCC	HEXA →	-0.350	-0.556	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016081 vs MAP3K9 — GBM

Explore this scatter interactively →