Synaptic vesicle docking

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle docking pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIC8B, STRN4, and WIPF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIC8B grouped by Synaptic vesicle docking-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RIC8B →	-0.363	-0.104	.001	.002	3	4
URINARY_TRACT	STRN4 →	+0.410	+0.127	.003	.003	3	4
OESOPHAGUS	WIPF1 →	+0.170	+0.139	.002	.002	3	4
OESOPHAGUS	SGK1 →	-0.120	-0.089	<.001	.009	3	4
LUNG_NSCLC_LUSC	APC →	+0.290	+0.127	.001	<.001	3	4
LUNG_NSCLC_LUSC	IL16 →	+0.375	+0.137	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIC8B by Synaptic vesicle docking activity — SOFT_TISSUE

Explore this box plot interactively →