Synaptic vesicle docking

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle docking pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB1, RSPO4, and PDCD5, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBB1 grouped by Synaptic vesicle docking-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TUBB1 →	-0.196	-0.711	.009	.009	3	1
LUNG_SCLC	RSPO4 →	+0.352	+0.626	.002	.002	3	1
LUNG_SCLC	PDCD5 →	+0.092	+0.666	.009	.001	3	1
LUNG_SCLC	CD4 →	-0.164	-0.579	<.001	.005	3	1
LUNG_SCLC	TGFBR1 →	-0.112	-0.657	.001	.004	3	1
LUNG_SCLC	EPHX2 →	+0.247	+0.699	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBB1 by Synaptic vesicle docking activity — LUNG_SCLC

Explore this box plot interactively →