Synaptic vesicle docking

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle docking pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Salubrinal, Linsitinib, and N25720-51-A1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Salubrinal grouped by Synaptic vesicle docking-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Salubrinal →	+0.528	+0.391	.016	.025	3	2
LUNG_SCLC	Linsitinib →	+0.318	+0.403	.043	.031	2	2
LUNG_SCLC	N25720-51-A1 →	-1.000	-0.500	.011	.012	2	2
LUNG_SCLC	A-770041 →	+0.811	+1.026	.003	.022	3	1
BLOOD_Lymphoma	Gefitinib →	+0.580	+0.651	.023	.011	2	2
BLOOD_Lymphoma	AZD4547 →	+0.973	+0.577	.001	.013	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Salubrinal by Synaptic vesicle docking activity — LUNG_SCLC

Explore this box plot interactively →