Synaptic vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VPS53, SMTN, and PHLDB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle exocytosis activity versus VPS53 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VPS53 →	+0.170	+0.110	<.001	<.001	3	6
COAD	SMTN →	-0.577	-0.020	.002	.002	3	6
CCRCC	PHLDB1 →	-0.322	-0.049	<.001	<.001	3	6
GBM	FERMT2_S159 →	-0.649	-0.087	<.001	.002	3	6
UCEC	VPS52 →	+0.151	+0.033	.001	.007	2	6
COAD	RSU1 →	-0.411	-0.020	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016079 vs VPS53 — GBM

Explore this scatter interactively →