Synaptic vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCHIP1, IQCJ-SCHIP1-AS1, and IKBIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle exocytosis activity versus SCHIP1 in LSCC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCHIP1 →	-0.661	-0.687	<.001	<.001	3	6
UCEC	IQCJ-SCHIP1-AS1 →	-0.685	-0.148	.005	.004	3	4
PDAC	IKBIP →	-0.370	-0.629	.001	.002	3	4
HNSC	BACH2 →	-0.506	-0.430	<.001	.005	3	4
LSCC	NAV1 →	-0.615	-0.447	.009	.007	3	4
LSCC	FBP1 →	+0.549	+0.364	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016079 vs SCHIP1 — LSCC

Explore this scatter interactively →