tRNA decay

Across TCGA patient cohorts, RNA activity of the tRNA decay pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POGZ, SMC2, and STAG2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA decay activity versus POGZ in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POGZ →	+0.231	+0.045	.001	<.001	3	8
BRCA	SMC2 →	+0.484	+0.030	<.001	<.001	3	6
GBM	STAG2 →	+0.253	+0.033	.001	<.001	3	6
BRCA	TK2 →	-0.285	-0.035	<.001	<.001	3	6
GBM	YTHDC1 →	+0.232	+0.039	<.001	<.001	3	6
GBM	ZMYM2 →	+0.313	+0.053	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016078 vs POGZ — GBM

Explore this scatter interactively →