snRNA catabolic process

Across TCGA patient cohorts, RNA activity of the snRNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NNMT, DCUN1D5, and GSTK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA catabolic process activity versus NNMT in PDAC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NNMT →	+0.307	+0.032	.001	.003	3	6
LSCC	DCUN1D5 →	+0.273	+0.047	.003	<.001	3	6
COAD	GSTK1 →	-0.433	-0.025	<.001	.001	3	5
PDAC	RBM7_S204 →	+0.340	+0.042	.005	.001	3	5
LUAD	RNF214 →	+0.211	+0.050	.003	<.001	3	5
CCRCC	SAR1B →	-0.285	-0.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016076 vs NNMT — PDAC

Explore this scatter interactively →