snRNA catabolic process

Across TCGA patient cohorts, RNA activity of the snRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOLPP1, DHX37, and EIF4H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA catabolic process activity versus DOLPP1 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DOLPP1 →	+0.487	+0.521	.003	.001	3	4
UCEC	DHX37 →	+0.572	+0.217	.007	.002	3	3
LUAD	EIF4H →	+0.264	+0.143	<.001	.002	3	3
LUAD	SP1 →	+0.175	+0.153	.006	.001	3	3
CCRCC	PWP1 →	+0.231	+0.163	.003	.009	3	3
CCRCC	ATP1A1 →	+0.409	+0.146	.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016076 vs DOLPP1 — BRCA

Explore this scatter interactively →