snRNA catabolic process

Across TCGA cell cohorts, RNA activity of the snRNA catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC10, ZCCHC8, and CETN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXOSC10 grouped by snRNA catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EXOSC10 →	-0.308	-0.280	.001	.002	3	6
BONE	ZCCHC8 →	-0.272	-0.432	.001	.005	3	5
STOMACH	CETN2 →	+0.189	+0.140	.003	.005	3	4
BLOOD_Myeloma	MTREX →	-0.543	-0.706	.004	.002	2	5
BLOOD_Myeloma	FUT3 →	-0.251	-0.423	<.001	.006	3	4
LUNG_NSCLC_LUAD	MAST2 →	+0.131	+0.163	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXOSC10 by snRNA catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →