sno(s)RNA metabolic process

Across TCGA cell cohorts, RNA activity of the sno(s)RNA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSBP, MAP7D1, and SMCO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FSBP grouped by sno(s)RNA metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FSBP →	+0.323	+0.174	<.001	<.001	3	5
SKIN	MAP7D1 →	-0.301	-0.285	<.001	.001	3	4
SKIN	SMCO3 →	+0.150	+0.258	<.001	<.001	3	4
SOFT_TISSUE	GYPA →	+0.468	+0.229	<.001	.009	3	4
LUNG_NSCLC_LUAD	CDH16 →	+0.202	+0.241	<.001	.006	3	4
BLOOD_Leukemia	FGF13 →	-0.292	-0.189	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FSBP by sno(s)RNA metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →