sno(s)RNA metabolic process

Across TCGA cell cohorts, RNA activity of the sno(s)RNA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, AHR, and CDK6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by sno(s)RNA metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TEAD1 →	-0.596	-0.106	.003	<.001	3	6
LUNG_SCLC	AHR →	+0.213	+0.080	.003	.003	3	5
PANCREAS	CDK6 →	-0.181	-0.075	<.001	.007	3	5
CNS	FDX2 →	+0.203	+0.055	.001	.002	3	5
LUNG_NSCLC_LUSC	CASP5 →	-0.228	-0.089	.005	.001	3	4
LIVER	ZC3H18 →	+0.689	+0.080	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by sno(s)RNA metabolic process activity — LIVER

Explore this box plot interactively →