sno(s)RNA metabolic process

Across TCGA cell cohorts, RNA activity of the sno(s)RNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QARS1, CYB5R1, and RPL32, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, sno(s)RNA metabolic process activity versus QARS1 in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	QARS1 →	+0.686	+0.240	.002	.005	3	6
LUNG_NSCLC_LUAD	CYB5R1 →	-1.304	-0.363	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	RPL32 →	+1.267	+0.355	.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	COPG1 →	-0.941	-0.257	.005	.007	3	6
LUNG_NSCLC_LUAD	EXOSC2 →	+0.443	+0.202	.002	.004	3	6
BREAST	SLC37A1 →	-1.280	-0.280	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016074 vs QARS1 — LUNG_SCLC

Explore this scatter interactively →