snRNA metabolic process

Across TCGA patient cohorts, RNA activity of the snRNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GOLM2, TMED2, and SPAG1_S418, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA metabolic process activity versus GOLM2 in CCRCC (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GOLM2 →	-0.320	-0.023	.001	.003	3	6
CCRCC	TMED2 →	-0.309	-0.023	.001	.003	3	5
BRCA	SPAG1_S418 →	-0.817	-0.026	.006	.004	3	5
BRCA	BCAP31 →	-0.463	-0.023	.004	.002	2	6
BRCA	COX4I1 →	-0.489	-0.028	<.001	<.001	3	5
CCRCC	MMP2 →	+0.792	+0.030	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016073 vs GOLM2 — CCRCC

Explore this scatter interactively →