snRNA metabolic process

Across TCGA patient cohorts, RNA activity of the snRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTH1R, KIF14, and ESPL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA metabolic process activity versus PTH1R in BRCA (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTH1R →	-0.623	-0.240	.004	.002	3	7
BRCA	KIF14 →	+0.788	+0.267	.004	<.001	3	6
BRCA	ESPL1 →	+0.684	+0.224	<.001	<.001	3	6
GBM	ZCCHC24 →	-0.716	-0.212	<.001	<.001	3	6
LSCC	TIMELESS →	+0.664	+0.190	<.001	<.001	3	6
LSCC	IFIT1P1 →	+0.316	+0.137	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016073 vs PTH1R — BRCA

Explore this scatter interactively →