rRNA metabolic process

Across TCGA patient cohorts, RNA activity of the rRNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC5L, RPRD2, and GATAD2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA metabolic process activity versus CDC5L in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDC5L →	+0.235	+0.034	<.001	<.001	3	6
LSCC	RPRD2 →	+0.252	+0.039	<.001	<.001	3	6
LSCC	GATAD2B →	+0.225	+0.040	<.001	<.001	3	6
LSCC	PRPF19 →	+0.218	+0.035	<.001	<.001	3	6
LSCC	THOC7 →	+0.199	+0.029	<.001	<.001	3	6
UCEC	ITPRID2_S316 →	-0.677	-0.089	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016072 vs CDC5L — LSCC

Explore this scatter interactively →