rRNA metabolic process

Across TCGA cell cohorts, RNA activity of the rRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, LRRC8B, and RPS27L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGALS1 grouped by rRNA metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LGALS1 →	+5.800	+0.305	<.001	<.001	3	6
BLOOD_Leukemia	LRRC8B →	-1.383	-0.216	.006	.003	3	6
CNS	RPS27L →	+0.854	+0.218	.009	.004	2	6
BLOOD_Lymphoma	BNIP3L →	+1.462	+0.323	.007	.003	3	5
LUNG_NSCLC_LUSC	RMND5A →	-1.146	-0.271	.009	.008	3	5
LUNG_NSCLC_LUSC	OVOL2 →	-1.946	-0.204	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGALS1 by rRNA metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →