rRNA metabolic process

Across TCGA cell cohorts, RNA activity of the rRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD63, HEXA, and PGAP3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA metabolic process activity versus CD63 in LUNG_NSCLC_LUSC (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CD63 →	-1.439	-0.346	.001	.001	2	8
LUNG_NSCLC_LUSC	HEXA →	-1.162	-0.434	.006	<.001	3	7
BREAST	PGAP3 →	-1.982	-0.231	<.001	.001	3	7
KIDNEY	PFAS →	+1.644	+0.323	<.001	.001	3	7
LUNG_SCLC	RPL12 →	+1.050	+0.343	.001	<.001	3	7
BLOOD_Leukemia	ZNF688 →	-0.631	-0.167	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016072 vs CD63 — LUNG_NSCLC_LUSC

Explore this scatter interactively →