Rhodopsin mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Rhodopsin mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCEH1, CD44, and HCK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rhodopsin mediated signaling pathway activity versus NCEH1 in CCRCC (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NCEH1 →	-0.782	-0.063	<.001	.002	3	6
CCRCC	CD44 →	-0.507	-0.064	.001	<.001	3	4
CCRCC	HCK →	-0.423	-0.070	<.001	<.001	3	4
BRCA	HK3 →	-0.491	-0.038	.001	.002	3	4
UCEC	KYNU →	-0.647	-0.063	.002	.002	3	4
CCRCC	STAT2 →	-0.307	-0.074	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016056 vs NCEH1 — CCRCC

Explore this scatter interactively →