Rhodopsin mediated signaling pathway

pathway activity — cross-omics
GO:0016056Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Rhodopsin mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18P11, CLEC4E, and EME2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCKRT18P11 →+0.192+0.293<.001<.00134
CCRCCCLEC4E →-0.654-0.211.004<.00133
HNSCEME2 →+0.480+0.156.009.00424
UCECMVK →+0.401+0.159.003.00633
UCECPROC →+0.660+0.211.003.00133
UCECNDUFA9 →+0.324+0.192.004.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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