Rhodopsin mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Rhodopsin mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR3C1, DPM1, and C3orf70, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR3C1 grouped by Rhodopsin mediated signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NR3C1 →	+3.971	+1.148	<.001	.004	3	3
BREAST	DPM1 →	+0.776	+1.003	.001	<.001	3	3
BONE	C3orf70 →	+1.400	+1.325	<.001	.006	3	3
SKIN	CELF6 →	-0.202	-0.826	.001	.001	3	3
SKIN	MMP2 →	+2.232	+0.729	.003	.001	3	3
KIDNEY	CRYGS →	-0.587	-1.056	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR3C1 by Rhodopsin mediated signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →