Rhodopsin mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Rhodopsin mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRK1, SAG, and DCBLD2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rhodopsin mediated signaling pathway activity versus GRK1 in LUNG_SCLC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GRK1 →	+1.113	+0.276	<.001	.003	3	14
BONE	SAG →	+1.444	+0.550	<.001	.001	3	13
SOFT_TISSUE	DCBLD2 →	-1.998	-0.103	.002	.002	3	10
LUNG_NSCLC_LUAD	GLIPR1 →	-1.874	-0.122	<.001	<.001	3	8
URINARY_TRACT	GNAT1 →	+0.124	+0.128	.001	.001	3	8
LUNG_NSCLC_LUSC	ARNTL2 →	-1.644	-0.211	.004	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016056 vs GRK1 — LUNG_SCLC

Explore this scatter interactively →