Carbohydrate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Carbohydrate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2I, PLK4, and PELI3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate biosynthetic process activity versus POLR2I in BRCA (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLR2I →	+0.829	+0.164	<.001	<.001	3	2
BRCA	PLK4 →	-0.959	-0.132	.001	.002	3	2
BRCA	PELI3 →	+0.678	+0.123	.007	.001	3	2
OV	GPRC5D →	-1.208	-0.145	.003	.004	3	2
COAD	TMEM151B →	+0.033	+0.107	.005	.006	3	2
COAD	ZKSCAN7 →	+0.452	+0.137	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016051 vs POLR2I — BRCA

Explore this scatter interactively →