Carbohydrate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Carbohydrate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRNKL1, CLBA1, and VPS37C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRNKL1 grouped by Carbohydrate biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CRNKL1 →	-0.954	-0.305	<.001	.009	3	4
BREAST	CLBA1 →	-0.947	-0.761	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	VPS37C →	-0.713	-0.332	.004	<.001	3	3
BREAST	MAPK11 →	-1.330	-0.734	.001	.001	3	3
BLOOD_Lymphoma	COMMD9 →	-0.823	-0.305	.006	.009	3	3
BLOOD_Lymphoma	TMEM43 →	-1.094	-0.402	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRNKL1 by Carbohydrate biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →