Carbohydrate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Carbohydrate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR4, DLG5, and ZYG11A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPAR4 grouped by Carbohydrate biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LPAR4 →	-0.190	-0.111	.006	.004	3	6
URINARY_TRACT	DLG5 →	+0.481	+0.102	.003	.001	3	4
BLOOD_Lymphoma	ZYG11A →	-0.430	-0.068	.005	.008	3	4
STOMACH	GPANK1 →	+0.123	+0.077	.001	<.001	3	4
LUNG_NSCLC_LUSC	DAGLB →	-0.400	-0.092	.004	.001	3	4
SOFT_TISSUE	TPM3 →	-0.207	-0.089	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPAR4 by Carbohydrate biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →