Detection of temperature stimulus

Across TCGA patient cohorts, RNA activity of the Detection of temperature stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANO1, IGFBP2, and HUWE1_S1907, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of temperature stimulus activity versus ANO1 in LSCC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANO1 →	+1.104	+0.098	<.001	<.001	3	7
LUAD	IGFBP2 →	+0.661	+0.042	<.001	<.001	3	6
COAD	HUWE1_S1907 →	-0.232	-0.029	<.001	.002	3	4
BRCA	MPP1 →	-0.333	-0.054	<.001	<.001	3	4
CCRCC	WDFY4 →	-0.383	-0.049	.001	.001	3	4
CCRCC	BTK →	-0.307	-0.038	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016048 vs ANO1 — LSCC

Explore this scatter interactively →