Detection of temperature stimulus

Across TCGA patient cohorts, RNA activity of the Detection of temperature stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADH1B, E2F2, and CRYZL2P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of temperature stimulus activity versus ADH1B in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADH1B →	+1.764	+0.714	<.001	<.001	3	4
BRCA	E2F2 →	-0.499	-0.511	.002	<.001	3	4
OV	CRYZL2P →	+0.604	+0.561	<.001	.001	3	4
GBM	KCNMA1 →	+0.621	+0.514	<.001	.001	3	3
CCRCC	RNU6-574P →	+0.381	+0.346	.006	.001	3	3
BRCA	FHL5 →	+0.671	+0.656	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016048 vs ADH1B — BRCA

Explore this scatter interactively →