Detection of temperature stimulus

Across TCGA cell cohorts, RNA activity of the Detection of temperature stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHO, CXCR4, and ZBTB49, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHO grouped by Detection of temperature stimulus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RHO →	-0.200	-0.843	<.001	<.001	3	5
LIVER	CXCR4 →	-0.327	-1.432	.008	.001	2	5
LUNG_NSCLC_LUAD	ZBTB49 →	-0.215	-0.707	<.001	.005	3	4
BREAST	ANO3 →	-0.191	-0.504	<.001	<.001	2	5
LARGE_INTESTINE	ALDH8A1 →	-0.127	-1.035	.005	<.001	3	3
LARGE_INTESTINE	OPN1SW →	-0.217	-0.908	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHO by Detection of temperature stimulus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →