Detection of bacterium

Across TCGA patient cohorts, RNA activity of the Detection of bacterium pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM22, INPP5D_S971, and RGS14_S203, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of bacterium activity versus TRIM22 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM22 →	+0.434	+0.055	<.001	.001	3	8
LSCC	INPP5D_S971 →	+0.659	+0.060	<.001	<.001	3	7
LSCC	RGS14_S203 →	+0.607	+0.041	<.001	<.001	3	6
LSCC	RGS14_S288 →	+0.669	+0.055	<.001	<.001	3	6
CCRCC	SH3BGRL3 →	+0.296	+0.061	<.001	<.001	3	6
LSCC	SIPA1_S55 →	+0.579	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016045 vs TRIM22 — LSCC

Explore this scatter interactively →