Detection of bacterium

Across TCGA patient cohorts, RNA activity of the Detection of bacterium pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP5, MEFV, and ADGRE2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of bacterium activity versus GBP5 in LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GBP5 →	+1.074	+0.255	<.001	.006	3	6
GBM	MEFV →	+0.664	+0.284	<.001	.001	3	6
GBM	ADGRE2 →	+0.705	+0.314	.002	<.001	3	6
LSCC	THEMIS2 →	+0.744	+0.436	<.001	<.001	3	6
BRCA	IL15 →	+0.476	+0.143	<.001	<.001	3	6
BRCA	HLA-DMA →	+0.755	+0.226	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016045 vs GBP5 — LUAD

Explore this scatter interactively →