Detection of bacterium

Across TCGA patient cohorts, RNA activity of the Detection of bacterium pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-A_S356, HLA-A, and HLA-A_S352, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of bacterium activity versus HLA-A_S356 in LSCC (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HLA-A_S356 →	+2.236	+0.518	<.001	<.001	3	9
OV	HLA-A →	+1.661	+0.683	<.001	<.001	3	8
LUAD	HLA-A_S352 →	+2.256	+0.469	<.001	<.001	3	8
UCEC	HLA-A_S359 →	+2.240	+0.390	<.001	<.001	3	7
GBM	TNFAIP8L2 →	+0.723	+0.313	<.001	<.001	3	6
GBM	VAV1 →	+0.539	+0.304	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016045 vs HLA-A_S356 — LSCC

Explore this scatter interactively →