Detection of bacterium

Across TCGA cell cohorts, RNA activity of the Detection of bacterium pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGMS1, MYO15B, and PARP16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGMS1 grouped by Detection of bacterium-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SGMS1 →	+0.742	+1.356	.003	.004	3	4
SKIN	MYO15B →	+0.882	+0.800	.008	.005	3	4
BLOOD_Lymphoma	PARP16 →	-1.053	-2.322	.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	ANKRD36B →	-1.656	-0.528	<.001	.001	3	3
LARGE_INTESTINE	MAOA →	+2.402	+1.028	.002	.008	3	3
PANCREAS	CCP110 →	+0.844	+1.241	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGMS1 by Detection of bacterium activity — PANCREAS

Explore this box plot interactively →