Detection of bacterium

Across TCGA cell cohorts, RNA activity of the Detection of bacterium pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAK3, FXR2, and SLC25A38, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of bacterium activity versus JAK3 in BLOOD_Lymphoma (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	JAK3 →	+3.151	+0.523	<.001	<.001	3	3
BLOOD_Lymphoma	FXR2 →	-0.900	-0.503	.002	<.001	3	3
BLOOD_Lymphoma	SLC25A38 →	-0.759	-0.502	<.001	<.001	3	3
BLOOD_Lymphoma	MAPK11 →	+1.899	+0.387	.006	<.001	3	3
SKIN	ABHD15 →	-1.061	-0.432	.001	.004	3	3
SKIN	NPW →	-0.302	-0.441	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016045 vs JAK3 — BLOOD_Lymphoma

Explore this scatter interactively →