Proton motive force-driven ATP synthesis

Across TCGA patient cohorts, RNA activity of the Proton motive force-driven ATP synthesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF2_S502, P4HB, and SDHAF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton motive force-driven ATP synthesis activity versus EEF2_S502 in CCRCC (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EEF2_S502 →	-0.793	-0.035	<.001	<.001	3	6
GBM	P4HB →	-0.373	-0.054	.002	<.001	3	5
COAD	SDHAF3 →	+0.741	+0.034	.006	.001	3	4
HNSC	AP4B1 →	-0.239	-0.079	<.001	.002	3	4
CCRCC	SUGT1_T265 →	-0.560	-0.028	.002	.006	3	4
GBM	THOC6 →	-0.242	-0.055	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015986 vs EEF2_S502 — CCRCC

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