Proton motive force-driven ATP synthesis

Across TCGA patient cohorts, RNA activity of the Proton motive force-driven ATP synthesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00460, PPIL4, and CEP170, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton motive force-driven ATP synthesis activity versus LINC00460 in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LINC00460 →	-0.329	-0.178	.006	.003	3	5
PDAC	PPIL4 →	-0.205	-0.170	.002	<.001	3	5
BRCA	CEP170 →	-0.432	-0.117	<.001	.003	3	4
LUAD	ADAMTS3 →	-0.638	-0.207	<.001	<.001	3	4
LSCC	ZNF22-AS1 →	-0.473	-0.163	<.001	<.001	3	4
LSCC	CYRIA →	-0.467	-0.144	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015986 vs LINC00460 — LSCC

Explore this scatter interactively →