Proton motive force-driven ATP synthesis

Across TCGA cell cohorts, RNA activity of the Proton motive force-driven ATP synthesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADIRF, INPP1, and CUEDC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADIRF grouped by Proton motive force-driven ATP synthesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADIRF →	-2.648	-0.234	<.001	<.001	3	4
BREAST	INPP1 →	-1.101	-0.234	.002	.009	3	4
BREAST	CUEDC1 →	+1.562	+0.479	<.001	<.001	3	4
BREAST	GRAMD4 →	+1.162	+0.430	<.001	<.001	3	4
STOMACH	SLC1A3 →	-3.378	-0.348	.002	.002	3	4
BREAST	HOOK2 →	+1.123	+0.403	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADIRF by Proton motive force-driven ATP synthesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →