Diadenosine polyphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Diadenosine polyphosphate catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT3, FHIT, and NUDT11, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT3 grouped by Diadenosine polyphosphate catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NUDT3 →	-0.362	-1.210	.001	.004	3	15
BLOOD_Myeloma	FHIT →	-0.432	-2.020	<.001	<.001	3	13
KIDNEY	NUDT11 →	-0.250	-1.077	.001	.008	3	11
BREAST	NUDT4 →	-0.254	-0.984	<.001	<.001	3	6
BONE	SOCS4 →	-0.260	-2.162	.009	<.001	3	6
BREAST	SPATA48 →	-0.277	-1.248	.009	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT3 by Diadenosine polyphosphate catabolic process activity — STOMACH

Explore this box plot interactively →