Diadenosine polyphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Diadenosine polyphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMT2, NUP93, and NDUFS8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NMT2 grouped by Diadenosine polyphosphate catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NMT2 →	+2.989	+1.847	.003	<.001	3	7
BLOOD_Lymphoma	NUP93 →	+0.735	+1.411	.001	<.001	3	5
BLOOD_Lymphoma	NDUFS8 →	+0.820	+1.633	.004	<.001	3	5
LUNG_NSCLC_LUAD	RBMS3 →	+1.186	+0.934	.002	.001	3	5
BREAST	ADORA2B →	+1.693	+0.987	.004	.006	3	5
BREAST	SEMA3A →	+1.614	+1.000	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NMT2 by Diadenosine polyphosphate catabolic process activity — URINARY_TRACT

Explore this box plot interactively →