Diadenosine polyphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Diadenosine polyphosphate catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H3, CSF1R, and IFT80, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZC3H3 grouped by Diadenosine polyphosphate catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZC3H3 →	+0.780	+0.499	<.001	.001	3	2
LUNG_SCLC	CSF1R →	+0.334	+1.733	.008	.006	2	2
LUNG_SCLC	IFT80 →	+0.306	+1.667	.003	.001	2	2
LUNG_SCLC	ALDH16A1 →	-0.220	-1.488	.005	.005	2	2
SKIN	CCNY →	-0.240	-0.439	<.001	.001	3	1
SKIN	KPNB1 →	+0.205	+0.238	.009	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZC3H3 by Diadenosine polyphosphate catabolic process activity — BREAST

Explore this box plot interactively →