Diadenosine polyphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Diadenosine polyphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMPPB, LMF1, and CCDC153, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diadenosine polyphosphate catabolic process activity versus GMPPB in LARGE_INTESTINE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GMPPB →	-0.561	-0.401	.002	.002	3	3
BREAST	LMF1 →	+1.986	+0.358	.001	.002	3	2
BREAST	CCDC153 →	-0.747	-0.417	<.001	.003	3	2
BLOOD_Myeloma	CBSL →	+6.024	+0.563	<.001	.003	2	3
LUNG_SCLC	PLAGL1 →	-3.683	-1.690	.008	<.001	3	2
LARGE_INTESTINE	NR2C1 →	-0.505	-0.409	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015961 vs GMPPB — LARGE_INTESTINE

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