Diadenosine polyphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Diadenosine polyphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT4, F2R, and PGM5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diadenosine polyphosphate metabolic process activity versus NUDT4 in HNSC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NUDT4 →	+0.594	+0.227	<.001	<.001	3	6
HNSC	F2R →	+0.705	+0.172	.001	.003	3	5
HNSC	PGM5 →	+0.912	+0.300	<.001	<.001	3	4
LSCC	FMNL2 →	-0.591	-0.247	.006	<.001	3	4
BRCA	CSNK2A3 →	-0.429	-0.146	.007	.003	3	4
UCEC	SERPINI1 →	+1.061	+0.213	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015959 vs NUDT4 — HNSC

Explore this scatter interactively →