Diadenosine polyphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Diadenosine polyphosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF2, ADD1, and ITLN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF2 grouped by Diadenosine polyphosphate metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TAF2 →	+0.354	+0.305	.008	.001	3	3
LUNG_SCLC	ADD1 →	-0.372	-0.398	.002	.003	3	3
LUNG_SCLC	ITLN1 →	+0.242	+0.295	.001	<.001	3	3
STOMACH	EFNB3 →	+0.221	+0.302	.006	.005	3	3
STOMACH	CDK7 →	-0.305	-0.325	.001	.004	3	3
SOFT_TISSUE	CYP2F1 →	-0.372	-0.268	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF2 by Diadenosine polyphosphate metabolic process activity — LUNG_SCLC

Explore this box plot interactively →