Diadenosine polyphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Diadenosine polyphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KARS1, MON1B, and NOB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diadenosine polyphosphate metabolic process activity versus KARS1 in BLOOD_Myeloma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KARS1 →	+0.904	+0.220	.004	.002	3	8
CNS	MON1B →	+0.784	+0.198	.004	.005	3	6
SKIN	NOB1 →	+0.693	+0.184	.005	.005	3	6
BREAST	CENPN →	+1.145	+0.268	<.001	.001	3	6
BREAST	TTC27 →	+0.514	+0.181	<.001	.008	2	7
BLOOD_Myeloma	RPA3 →	+1.502	+0.186	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015959 vs KARS1 — BLOOD_Myeloma

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