Nucleobase-containing small molecule interconversion

Across TCGA patient cohorts, RNA activity of the Nucleobase-containing small molecule interconversion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AK4, DOCK2_S1706, and ARHGAP9_S500, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule interconversion activity versus AK4 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AK4 →	+0.557	+0.065	.003	<.001	3	6
LSCC	DOCK2_S1706 →	+0.813	+0.035	<.001	.006	3	5
PDAC	ARHGAP9_S500 →	+0.438	+0.036	.006	.001	3	5
GBM	ADD3_S650 →	+0.868	+0.062	<.001	<.001	3	5
GBM	KIF13B_S1379 →	+0.271	+0.039	.003	.001	3	5
LSCC	SHROOM2_S1173 →	-0.754	-0.056	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015949 vs AK4 — LUAD

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