Nucleobase-containing small molecule interconversion

Across TCGA cell cohorts, RNA activity of the Nucleobase-containing small molecule interconversion pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A6OS, DAB1, and CILK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC7A6OS grouped by Nucleobase-containing small molecule interconversion-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SLC7A6OS →	+0.236	+0.142	<.001	.008	3	5
LARGE_INTESTINE	DAB1 →	-0.210	-0.139	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CILK1 →	+0.211	+0.240	.001	.005	3	4
LUNG_NSCLC_LUSC	BLZF1 →	+0.222	+0.248	.001	.001	3	4
LUNG_NSCLC_LUSC	HAT1 →	-0.219	-0.196	<.001	.002	3	4
LUNG_NSCLC_LUSC	RIPK1 →	+0.238	+0.268	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC7A6OS by Nucleobase-containing small molecule interconversion activity — KIDNEY

Explore this box plot interactively →