Nucleobase-containing small molecule interconversion

Across TCGA cell cohorts, RNA activity of the Nucleobase-containing small molecule interconversion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSTA, PPAT, and AKAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule interconversion activity versus CSTA in BLOOD_Leukemia (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CSTA →	-4.732	-0.229	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	PPAT →	+0.877	+0.227	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	AKAP1 →	+1.075	+0.232	<.001	<.001	3	5
SKIN	POP1 →	+0.798	+0.261	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	LETM1 →	+1.216	+0.197	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	UBE3D →	+0.578	+0.228	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015949 vs CSTA — BLOOD_Leukemia

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