Nucleobase-containing small molecule interconversion

Across TCGA cell cohorts, RNA activity of the Nucleobase-containing small molecule interconversion pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AK1, GLRX, and PSMD9, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule interconversion activity versus AK1 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AK1 →	+1.710	+0.301	<.001	<.001	3	14
LARGE_INTESTINE	GLRX →	+2.574	+0.426	<.001	<.001	3	13
URINARY_TRACT	PSMD9 →	+2.107	+0.347	.004	.004	3	13
URINARY_TRACT	TXNDC17 →	+2.340	+0.369	.007	.001	3	13
BONE	HINT1 →	+2.070	+0.323	<.001	.001	2	14
SOFT_TISSUE	RANBP3 →	+1.948	+0.469	.007	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015949 vs AK1 — OESOPHAGUS

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