Formate metabolic process

Across TCGA patient cohorts, RNA activity of the Formate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFS, TTC21A, and SYNGAP1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formate metabolic process activity versus MTHFS in ACC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	MTHFS →	+1.218	+0.075	<.001	<.001	2	29
SCLC	TTC21A →	-0.639	-0.903	<.001	<.001	3	21
DLBC	SYNGAP1 →	-1.374	-0.125	<.001	<.001	3	21
SCLC	ZNF169 →	-0.794	-1.031	<.001	<.001	3	20
ACC	IMP3 →	+0.730	+0.073	<.001	<.001	3	20
ACC	COX5A →	+1.078	+0.087	<.001	<.001	2	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015942 vs MTHFS — ACC

Explore this scatter interactively →