Formate metabolic process

Across TCGA patient cohorts, RNA activity of the Formate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTHFD1L, DDX21_S71, and CDC42EP4_S64, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formate metabolic process activity versus MTHFD1L in BRCA (Pearson r = 0.83).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTHFD1L →	+0.817	+0.098	<.001	<.001	3	9
LUAD	DDX21_S71 →	+1.272	+0.116	<.001	.005	3	6
LUAD	CDC42EP4_S64 →	-0.648	-0.085	.007	.008	3	5
PDAC	GARS1 →	+0.207	+0.084	.001	<.001	3	5
HNSC	RFX5 →	-0.388	-0.166	.001	<.001	3	5
HNSC	RPL18A_S123 →	+0.522	+0.135	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015942 vs MTHFD1L — BRCA

Explore this scatter interactively →